Last update: Nov. 21, 2018

Amlodipine

Very Low Risk for breastfeeding


Safe. Compatible.
Minimal risk for breastfeeding and infant.

It is excreted into breast milk in low (Aoki 2018, Naito 2015) or undetectable concentration (Morgan 2018), without problems observed in infants whose mothers were on treatment with this drug. (Naito 2015, Szucs 2010, Ahn 2007).
When measured, the plasma levels of drug in these infants were undetectable (Aoki 2018, Morgan 2018, Vasa 2013 S15-poster 29).

Because its drug elimination period is very prolonged, safer known alternatives may be preferable, especially during the neonatal period and in case of premature infant.
However, the measurements, which have been undetectable, have been made in newborns, in the first week of life, and several of them were premature (Aoki 2018).

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Amlodipine is also known as


Amlodipine in other languages or writings:

Group

Amlodipine belongs to this group or family:

Tradenames

Main tradenames from several countries containing Amlodipine in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 60 - 65 %
Molecular weight 409 daltons
Protein Binding 93 - 98 %
VD 21 l/Kg
pKa 8,7 -
Tmax 6 - 12 hours
T1/2 35 - 65 hours
M/P ratio 0,74 -
Theoretical Dose 0,0015 - 0,0042 mg/Kg/d
Relative Dose 4,2 (0,9 - 7,3) %
Relat.Ped.Dose 1,5 - 4,2 %

References

  1. Morgan JL, Kogutt BK, Meek C, Stehel EK, McIntire DD, Sheffield JS, Roberts SW. Pharmacokinetics of amlodipine besylate at delivery and during lactation. Pregnancy Hypertens. 2018 Abstract
  2. Aoki H, Ito N, Kaniwa N, Saito Y, Wada Y, Nakajima K, Sago H, Murashima A, Okamoto A, Ito S. Low Levels of Amlodipine in Breast Milk and Plasma. Breastfeed Med. 2018 Abstract
  3. Malachias MV, Figueiredo CE, Sass N, Antonello IC, Torloni MR, Bortolotto MRF L. 7th Brazilian Guideline of Arterial Hypertension: Chapter 9 - Arterial Hypertension in pregnancy Arq Bras Cardiol. 2016 Abstract Full text (link to original source) Full text (in our servers)
  4. Naito T, Kubono N, Deguchi S, Sugihara M, Itoh H, Kanayama N, Kawakami J. Amlodipine passage into breast milk in lactating women with pregnancy-induced hypertension and its estimation of infant risk for breastfeeding. J Hum Lact. 2015 Abstract
  5. Vasa R, Martha Ramirez M. Amlodipine exposure through breastfeeding in a 32 week preterm newborn. Breastfeeding Med. 2013;8 (Suppl 1):S15. Breastfeeding Med; 8 (Suppl 1):S15. 2013 Full text (link to original source) Full text (in our servers)
  6. Amlodipine Data Sheet 2013 Full text (in our servers)
  7. Szucs KA, Axline SE, Rosenman MB. Maternal membranous glomerulonephritis and successful exclusive breastfeeding. Breastfeed Med. 2010 Abstract
  8. Ahn HK, Nava-Ocampo AA, Han JY, Choi JS, Chung JH, Yang JH, Koong MK, Park CT. Exposure to amlodipine in the first trimester of pregnancy and during breastfeeding. Hypertens Pregnancy. 2007 Abstract
  9. Amlodipino Ficha técnica 2007 Full text (in our servers)
  10. Meredith PA, Elliott HL. Clinical pharmacokinetics of amlodipine. Clin Pharmacokinet. 1992 Abstract

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