Last update: June 4, 2016

Verapamil Hydrochloride

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

It is excreted in breast milk in clinically non-significant amount and no problems have been observed in infants whose mothers were receiving this treatment.
Plasma levels in these infants were undetectable or very low.

Verapamil may induce to an increase of plasma Prolactin levels.

American Academy of Pediatrics: usually compatible with breastfeeding medication.
WHO List of Essential Medicines 2002: compatible with breastfeeding.

Alternatives

We do not have alternatives for Verapamil Hydrochloride since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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José María Paricio, founder of e-lactancia.
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Other names

Verapamil Hydrochloride is also known as


Verapamil Hydrochloride in other languages or writings:

Group

Verapamil Hydrochloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Verapamil Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Bioavailability 20 - 30 %
Molecular weight 491 daltons
Protein Binding 90 %
VD 3 - 6 l/Kg
Tmax 1 - 2 hours
T1/2 2 - 8 hours
M/P ratio 0,9 -
Theoretical Dose 0,04 mg/Kg/d
Relative Dose 0,6 %
Relat.Ped.Dose 0,8 %

References

  1. Malachias MV, Figueiredo CE, Sass N, Antonello IC, Torloni MR, Bortolotto MRF L. 7th Brazilian Guideline of Arterial Hypertension: Chapter 9 - Arterial Hypertension in pregnancy Arq Bras Cardiol. 2016 Abstract Full text (link to original source) Full text (in our servers)
  2. Serrano Aguayo P, García de Quirós Muñoz JM, Bretón Lesmes I, Cózar León MV. Tratamiento de enfermedades endocrinológicas durante la lactancia. [Endocrinologic diseases management during breastfeeding.] Med Clin (Barc). 2015 Abstract
  3. Davanzo R, Bua J, Paloni G, Facchina G. Breastfeeding and migraine drugs. Eur J Clin Pharmacol. 2014 Abstract
  4. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  5. Pringsheim T, Davenport W, Mackie G, Worthington I, Aubé M, Christie SN, Gladstone J, Becker WJ; Canadian Headache Society Prophylactic Guidelines Development Group. Canadian Headache Society guideline for migraine prophylaxis. Can J Neurol Sci. 2012 Abstract Full text (in our servers)
  6. Jürgens TP, Schaefer C, May A. Treatment of cluster headache in pregnancy and lactation. Cephalalgia. 2009 Abstract
  7. Krysiak R, Okopieh B, Herman ZS. [Verapamil-induced hyperprolactinemia--a case report]. Pol Arch Med Wewn. 2005 Abstract
  8. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  9. Tan HL, Lie KI. Treatment of tachyarrhythmias during pregnancy and lactation. Eur Heart J. 2001 Abstract Full text (link to original source) Full text (in our servers)
  10. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  11. Kelley SR, Kamal TJ, Molitch ME. Mechanism of verapamil calcium channel blockade-induced hyperprolactinemia. Am J Physiol. 1996 Abstract
  12. Miller MR, Withers R, Bhamra R, Holt DW. Verapamil and breast-feeding. Eur J Clin Pharmacol. 1986 Abstract
  13. Inoue H, Unno N, Ou MC, Iwama Y, Sugimoto T. Level of verapamil in human milk. Eur J Clin Pharmacol. 1984 Abstract
  14. de Swiet M. Excretion of verapamil in human milk. Br Med J (Clin Res Ed). 1984 Abstract Full text (link to original source) Full text (in our servers)
  15. Andersen HJ. Excretion of verapamil in human milk. Eur J Clin Pharmacol. 1983 Abstract

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