Last update: July 6, 2018

A03AAxx

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

A product which has antimuscarinic/anticholinergic effects, similar in action to atropine.
It has antispasmodic properties on smooth muscle. Indicated in functional conditions of the intestine, gall bladder, uterus and bladder.

Since the last update, we have not found published data on its excretion in breastmilk.

Its high binding to plasma proteins makes its excretion in milk unlikely, as indicated by the manufacturer (Unipharm 2018).

There is hardly any published scientific data on this product: fewer than 10 articles (only 4 on humans) collected in PubMed and the last one dates from 2001.

Until there is more published information about this drug in relation to breastfeeding, better known alternatives may be preferable, especially during the neonatal period and in case of prematurity.
Atropine in isolated doses is considered compatible with breastfeeding.

During breastfeeding it may be prudent to avoid it or take a minimum dose over short periods of time, monitoring the production of milk as anticholinergics can reduce milk production (De Martino 1980, Bizarro 1980) especially in the first weeks postpartum. It is also advisable to monitor anticholinergic symptoms in the infant: dry mouth, constipation...

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

A03AAxx is Pargeverine Hydrochloride in ATC Code/s.

Is written in other languages:

A03AAxx is also known as

Tradenames

Main tradenames from several countries containing A03AAxx in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 75 ± 13 %
Molecular weight 374 daltons
Protein Binding 91 - 97 %
VD 0,12 - 2 l/Kg
Tmax 0,9 - 1 hours
T1/2 4 hours
M/P ratio 0,1 -

References

  1. Unipharm. Propinox (espasmo dolofor). Ficha técnica. 2018 Full text (link to original source) Full text (in our servers)
  2. Roemmers. Propinox (Sertal). Prospecto. 2017 Full text (in our servers)
  3. de los Santos AR, Zmijanovich R, Pérez Macri S, Martí ML, Di Girolamo G. Antispasmodic/analgesic associations in primary dysmenorrhea double-blind crossover placebo-controlled clinical trial. Int J Clin Pharmacol Res. 2001 Abstract
  4. Bizzarro A, Iannucci F, Tolino A, Soricelli A, Guarino G, Verdoliva A. Inhibiting effect of atropine on prolactin blood levels after stimulation with TRH. Clin Exp Obstet Gynecol. 1980 Abstract
  5. De Martino F, De Matteo A, L'Abbate V, Soricelli A, Fontana A, Petrenga E, Cesarone M. [Inhibitory effects of atropine on serum prolactin levels after TRH stimulation]. Boll Soc Ital Biol Sper. 1980 Abstract

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