Last update: Feb. 1, 2017

Otilonium Bromide

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

Anticholinergic drug used as spasmolytic for functional gastrointestinal disorders.

At latest update relevant published data on excretion into breast milk were not found.

It acts locally on the intestinal mucosa. Absorption through the intestine is practically absent (Evangelista 2004, Catalogo 2008), with an excretion being almost 100% unmodified in feces that is determinant for the extremely low levels reached in the plasma (Zhao 2010: <0.02 mg / L), which causes the passage through breastmilk in significant amounts must be very unlikely.
Side effects are mild and very rarely seen.

Although anticholinergics may reduce milk production, however, because of its poor absorption it would not be the case with Otilonium.

Alternatives

We do not have alternatives for Otilonium Bromide since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Otilonium Bromide in other languages or writings:

Group

Otilonium Bromide belongs to this group or family:

Tradenames

Main tradenames from several countries containing Otilonium Bromide in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 3 %
Molecular weight 564 daltons
Tmax 1,5 hours

References

  1. AEMPS. Otilonio. Ficha técnica. 2015 Full text (in our servers)
  2. Zhao YR, Ding L, Fan HW, Yu Y, Qi XM, Leng Y, Rao YK. Determination of the unstable drug otilonium bromide in human plasma by LC-ESI-MS and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Abstract
  3. Catalioto RM, Triolo A, Giuliani S, Altamura M, Evangelista S, Maggi CA. Increased paracellular absorption by bile salts and P-glycoprotein stimulated efflux of otilonium bromide in Caco-2 cells monolayers as a model of intestinal barrier. J Pharm Sci. 2008 Abstract
  4. Evangelista S. Quaternary ammonium derivatives as spasmolytics for irritable bowel syndrome. Curr Pharm Des. 2004 Abstract

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