Last update: Feb. 20, 2018

(1R)-1-(3-Hydroxyphenyl)-2-methylaminoethanol

Low Risk probable for breastfeeding


Moderately safe.
Mild risk possible. Follow up recommended.
Read the Comment.

A sympathomimetic with alpha-adrenergic action. It produces peripheral vasoconstriction and increased blood pressure without stimulating effects on the central nervous system.

Used as decongestant in topical nasal preparations at low concentration, in association with other drugs, in oral preparations to treat respiratory catarrh (Nice 2000, Kanfer 1993) and in eye drops at concentrations of up to 10% as a mydriatic. It is also used subcutaneously or intramuscularly in severe hypotensive states and in association with topical anesthetics.

Since the last update, we have not found published data on its excretion in breast milk.

The low dose of phenylephrine in nasal, ophthalmic and topical preparations makes its unlikely that it will transfer into breastmilk in significant amounts. It is prudent to press on the tear glands after adminitering eye drops in order to reduce absorption.

Its low oral bioavailability complicates its transfer to the infant’s plasma from ingested breastmilk, except in premature babies and the immediate neonatal period in which there may be increased intestinal permeability.

Nasal and ophthalmic use is authorized in children under one year of age.

Avoid excessive or prolonged oral use and use the minimum sufficient dose.

A similar molecule, pseudoephedrine, can cause a decrease in milk production (Aljazaf 2003).


See below the information of this related product:

Alternatives

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Other names

(1R)-1-(3-Hydroxyphenyl)-2-methylaminoethanol is Phenylephrine in Chemical name.

Is written in other languages:

(1R)-1-(3-Hydroxyphenyl)-2-methylaminoethanol is also known as

Groups

(1R)-1-(3-Hydroxyphenyl)-2-methylaminoethanol belongs to these groups or families:

Tradenames

Main tradenames from several countries containing (1R)-1-(3-Hydroxyphenyl)-2-methylaminoethanol in its composition:

List of 79 tradenames

Pharmacokinetics

Variable Value Unit
Bioavailability 38 %
Molecular weight 204 daltons
VD 0,6 l/Kg
pKa 8,8 -
Tmax 0,2 - 1 hours
T1/2 2 - 3 hours

References

  1. Aljazaf K, Hale TW, Ilett KF, Hartmann PE, Mitoulas LR, Kristensen JH, Hackett LP. Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol. 2003 Abstract Full text (link to original source) Full text (in our servers)
  2. Nice FJ, Snyder JL, Kotansky BC. Breastfeeding and over-the-counter medications. J Hum Lact. 2000 Abstract
  3. Kanfer I, Dowse R, Vuma V. Pharmacokinetics of oral decongestants. Pharmacotherapy. 1993 Abstract

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