Last update Nov. 20, 2024

Xenon-133; Xenon-127

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Xenon-133 and Xenon-127 are radioactive isotopes of Xenon, a noble gas present in the atmosphere. They are used to measure pulmonary and cerebral blood flow. Inhaled administration.

Although the radioactive half-life of Xenon-133 is 5 days and that of Xenon-127 is 36 days, Xenon is neither absorbed nor passes into plasma significantly after inhalation, being expired within a few minutes. Its biological half-life is practically nil. It is a gas that in its natural non-radioactive form is used in anesthesia and is not known to be excreted in breast milk. (Stuttmann 2010).

Several societies and expert authors consider that no interruption of breastfeeding is necessary after a scan with radioactive Xenon isotopes. (Hale, Mattsson 2021, ICRP 2015 & 2008, Parker 2012, Stabin 2000)

Alternatives

We do not have alternatives for Xenon-133; Xenon-127.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Xenon-133; Xenon-127 is also known as


Group

Xenon-133; Xenon-127 belongs to this group or family:

Pharmacokinetics

Variable Value Unit
T½ X133/127: 127/864. Biol: 0.1 hours

References

  1. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  2. Mattsson S, Leide-Svegborn S, Andersson M. X-RAY AND MOLECULAR IMAGING DURING PREGNANCY AND BREASTFEEDING-WHEN SHOULD WE BE WORRIED? Radiat Prot Dosimetry. 2021 Oct 12;195(3-4):339-348. Abstract Full text (link to original source)
  3. ICRP 2015: Mattsson S, Johansson L, Leide Svegborn S, Liniecki J, Noßke D, Riklund KÅ, Stabin M, Taylor D, Bolch W, Carlsson S, Eckerman K, Giussani A, Söderberg L, Valind S; ICRP.. Radiation Dose to Patients from Radiopharmaceuticals: a Compendium of Current Information Related to Frequently Used Substances. ANNEX D. RECOMMENDATIONS ON BREAST-FEEDING INTERRUPTIONS. p 320-21. ICRP Publication 128. Ann. ICRP 44(2S). 2015. Table D1 p320-21. Abstract Full text (link to original source)
  4. Parker JA, Coleman RE, Grady E, Royal HD, Siegel BA, Stabin MG, Sostman HD, Hilson AJ; Society of Nuclear Medicine. SNM practice guideline for lung scintigraphy 4.0. J Nucl Med Technol. 2012 Mar;40(1):57-65. Abstract Full text (link to original source)
  5. Stuttmann R, Schäfer C, Hilbert P, Meyer MR, Maurer HH. The breast feeding mother and xenon anaesthesia: four case reports. Breast feeding and xenon anaesthesia. BMC Anesthesiol. 2010 Abstract Full text (link to original source) Full text (in our servers)
  6. ICRP. Radiation dose to patients from radiopharmaceuticals. Addendum 3 to ICRP Publication 53. ICRP Publication 106. Annex D. Recommendations on breast-feeding interruptions, p. 163-165. Ann ICRP. 2008 Abstract Full text (link to original source) Full text (in our servers)
  7. Stabin MG, Breitz HB. Breast milk excretion of radiopharmaceuticals: mechanisms, findings, and radiation dosimetry. J Nucl Med. 2000 Abstract Full text (link to original source) Full text (in our servers)

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