Last update July 16, 2023

Varicella-zoster immunoglobulin

Compatible

Safe substance and/or breastfeeding is the best option.

Human varicella-zoster immune globulin is an antibody solution obtained from the plasma of selected donors who have antibodies to human herpesvirus 3 (varicella-zoster virus 1). It is used for postexposure prophylaxis of varicella infections in high-risk populations, as well as to reduce the severity of infections.

Its very high molecular weight makes it very unlikely to pass into breast milk in clinically significant quantities.

Due to its protein nature, it is inactivated in the gastrointestinal tract and is not absorbed (oral bioavailability practically nil), which makes it difficult or impossible for it to pass into the infant's plasma from ingested breast milk, except in premature infants and in the immediate neonatal period, where there may be greater intestinal permeability.

It can be administered intramuscularly to infants weighing less than 2 kg.

Expert authors consider the use of this medication safe during breastfeeding. (LactMed, Briggs 2015)

 


See below the information of this related product:

Alternatives

We do not have alternatives for Varicella-zoster immunoglobulin since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Varicella-zoster immunoglobulin in other languages or writings:

Group

Varicella-zoster immunoglobulin belongs to this group or family:

Tradenames

Main tradenames from several countries containing Varicella-zoster immunoglobulin in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 160.000 daltons
Tmax 3 hours
432 - 720 hours

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Saol. VariZIG. Drug Summary. 2017 Full text (in our servers)
  3. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015

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