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Human varicella-zoster immune globulin is an antibody solution obtained from the plasma of selected donors who have antibodies to human herpesvirus 3 (varicella-zoster virus 1). It is used for postexposure prophylaxis of varicella infections in high-risk populations, as well as to reduce the severity of infections.
Its very high molecular weight makes it very unlikely to pass into breast milk in clinically significant quantities.
Due to its protein nature, it is inactivated in the gastrointestinal tract and is not absorbed (oral bioavailability practically nil), which makes it difficult or impossible for it to pass into the infant's plasma from ingested breast milk, except in premature infants and in the immediate neonatal period, where there may be greater intestinal permeability.
It can be administered intramuscularly to infants weighing less than 2 kg.
Expert authors consider the use of this medication safe during breastfeeding. (LactMed, Briggs 2015)
See below the information of this related product: