Last update Nov. 8, 2024

Umeclidinium Bromide

Compatible

Safe product and/or breastfeeding is the best option.

Umeclidinium is a long-acting quaternary ammonium antimuscarinic that is used similarly to ipratropium as a maintenance treatment for symptoms of chronic obstructive pulmonary disease. Inhaled administration.

At the date of last update we found no published data on its excretion in breast milk.

Its pharmacokinetic data (large volume of distribution, moderately high molecular weight and high percentage of protein binding) make it very unlikely to pass into breast milk in clinically significant quantities.

Its negligible oral bioavailability makes it difficult for it to pass into infant plasma from ingested breast milk, except in premature infants and the immediate neonatal period in which there may be greater intestinal permeability.

Several medical societies and expert authors consider safe the use of this drug during breastfeeding. (Lactmed, Bendien 2024).

Alternatives

We do not have alternatives for Umeclidinium Bromide since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Umeclidinium Bromide in other languages or writings:

Group

Umeclidinium Bromide belongs to this group or family:

Tradenames

Main tradenames from several countries containing Umeclidinium Bromide in its composition:

List of 8 tradenames
  • Anoro™. Contains other elements than Umeclidinium Bromide in its composition
  • Anoro (Аноро)™. Contains other elements than Umeclidinium Bromide in its composition
  • Elebrato™. Contains other elements than Umeclidinium Bromide in its composition
  • Incruse™
  • Laventair™. Contains other elements than Umeclidinium Bromide in its composition
  • Rolufta™
  • Temybric™. Contains other elements than Umeclidinium Bromide in its composition
  • Trelegy™. Contains other elements than Umeclidinium Bromide in its composition

Pharmacokinetics

Variable Value Unit
Oral Bioavail. ≈ 0. (Inhal: 13) %
Molecular weight 509 daltons
Protein Binding 89 %
VD 1.2 l/Kg
pKa 13.04 -
Tmax 0.1 - 0.25 hours
T½ 11 - 19 hours

References

  1. Bendien SA, de Kruif MD, Feitsma H, van Hoolwerff-Blikkendaal C, Huurne KK, Kuiterman A, Baranova EV, Wittkamp A, Brons A, Poulissen M, van der Meer AN. Summary of the Dutch Multidisciplinary Practice Guideline on Asthma and Pregnancy. J Allergy Clin Immunol Pract. 2024 Jul;12(7):1751-1762. Consulted on Nov. 7, 2024 Abstract
  2. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)

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