Last update Aug. 6, 2022
It is a non-depolarizing muscle relaxant drug with a peripheral action that is used as premedication for endotracheal intubation, general anesthesia and mechanical ventilation. Tubocurarine chloride has also been used to control muscle spasms in tetanus. Intravenous administration.
It is one of the active principles of curare, which is obtained from the stem of the Chondodendron tomentosum plant. It has been withdrawn from the market and replaced by other drugs with fewer side effects and faster elimination.
At latest update, no relevant published data concerning excretion into breast milk were found.
Quaternary ammonium muscle relaxants are poorly absorbed from the gastro-intestinal tract; its low oral bioavailability renders the pass of this agent to the infant's plasma highly unlikely. (Dalal 2014, Spigset 1994)
However, other muscle relaxants with a more rapid elimination time period and better known drugs are preferred.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM