Last update Jan. 12, 2024

Циклизин

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Cyclizine is a first generation antihistamine and antiemetic drug derived from piperazine used for the prevention and treatment of nausea, vomiting and dizziness associated with motion sickness and vertigo and in Ménière's vertigo. Moderate sedative effect. Oral administration up to three times a day.

At the time of the last update, we found no published data on its excretion in breast milk.

The scarce pharmacokinetic data published do not allow predicting its possible excretion in breast milk, although some authors consider it moderate. (Solhaug 2004)

Pending further published data on this drug in relation to lactation, safer known alternatives may be preferable, especially during the neonatal period and in case of prematurity. (Nice 2000)

Alternatives

  • Dimenhydrinate (Safe substance and/or breastfeeding is the best option.)
  • Diphenhydramine (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Циклизин is Cyclizine in Cyrillic.

Is written in other languages:

Циклизин is also known as

Group

Циклизин belongs to this group or family:

Tradenames

Main tradenames from several countries containing Циклизин in its composition:

List of 14 tradenames

Pharmacokinetics

Variable Value Unit
Molecular weight 266 daltons
VD 23 (12-30) l/Kg
T½ 13 (7-48) hours

References

  1. Vella-Brincat JW, Begg EJ, Jensen BP, Chin PK, Roberts RL, Fairhall M, Macleod SA, Reid K. The pharmacokinetics and pharmacogenetics of the antiemetic cyclizine in palliative care patients. J Pain Symptom Manage. 2012 Mar;43(3):540-8. Abstract
  2. Solhaug V, Roland PD. Bruk av antihistaminer under graviditet og amming \ [Use of antihistaminics during pregnancy and breast feeding]. Tidsskr Nor Laegeforen. 2004 Abstract Full text (link to original source) Full text (in our servers)
  3. Nice FJ, Snyder JL, Kotansky BC. Breastfeeding and over-the-counter medications. J Hum Lact. 2000 Nov;16(4):319-31. Review. Erratum in: J Hum Lact 2001 Feb;17(1):90. Abstract

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