Last update Nov. 24, 2023

Trolamine, Triethanolamine Salicylate

Compatible

Safe substance and/or breastfeeding is the best option.

Trolamine is the salt formed by combining salicylic acid and triethanolamine. It is used to reduce certain skin stains, remove earwax, prevent radiation-induced dermatitis, as a sunscreen, topical analgesic balm and in cosmetics. Topical application.

At the time of the last update, we found no published data on its excretion in breast milk.

Cutaneous absorption is less than 10% (Hale, Cross 1998 & 1997, Morra 1996), so the levels reached in plasma are very low and passage into breast milk is not likely to be significant.

Trolamine salts may irritate the skin and mucous membranes and cause contact dermatitis.

Do not apply on the breast, or clean the breast and hands well before breastfeeding.

Alternatives

We do not have alternatives for Trolamine, Triethanolamine Salicylate since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Trolamine, Triethanolamine Salicylate in other languages or writings:

Groups

Trolamine, Triethanolamine Salicylate belongs to these groups or families:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. dermat: <10; oral: significant %
Molecular weight 287 daltons
Protein Binding 50 - 90 %
pKa 15.12 -
T½ 1 - 2 hours

References

  1. AEMPS. Trietanolamina (Bexidermil) Ficha técnica. 2022 Full text (in our servers)
  2. Cross SE, Anderson C, Roberts MS. Topical penetration of commercial salicylate esters and salts using human isolated skin and clinical microdialysis studies. Br J Clin Pharmacol. 1998 Abstract Full text (in our servers)
  3. Cross SE, Anderson C, Thompson MJ, Roberts MS. Is there tissue penetration after application of topical salicylate formulations? Lancet. 1997 Abstract
  4. Morra P, Bartle WR, Walker SE, Lee SN, Bowles SK, Reeves RA. Serum concentrations of salicylic acid following topically applied salicylate derivatives. Ann Pharmacother. 1996 Abstract

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