Last update Sept. 3, 2022

Trimethobenzamide Hydrochloride

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

It is a sedative antihistamine, derived from monoethanolamine, which is used as an antiemetic in the control of nausea and vomiting. Intramuscular administration 3 to 4 times a day.

At the date of the last update we did not find any published data on its excretion in breast milk.

The scarcity of known pharmacokinetic data does not allow to predict the magnitude of its possible excretion in breast milk.

It is a drug with very few bibliographical references and marketed in few countries.

Some authors consider it a drug probably compatible with lactation. (Briggs 2015, Mahadevan 2006)

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.

Alternatives

  • Metoclopramide ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Ondansetron ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Trimethobenzamide Hydrochloride in other languages or writings:

Groups

Trimethobenzamide Hydrochloride belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Trimethobenzamide Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Alta - Hig %
pKa 14.68 -
Tmax 0.5 - 0.75 hours
7 - 9 hours

References

  1. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  2. Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 2006 Jul;131(1):283-311. Review. Abstract Full text (link to original source) Full text (in our servers)

Total visits

3,873

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at elactancia.org@gmail.com

e-lactancia is a resource recommended by Asociación Española de Bancos de Leche Humana of Spain

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM