Last update Dec. 31, 2022

Travoprost

Compatible

Safe product and/or breastfeeding is the best option.

It is a synthetic analogue of dinoprost (prostaglandin F2α). It is used in the treatment of open-angle glaucoma and ocular hypertension. Ophthalmic topical administration.

At the date of the last update we did not find any published data on its excretion in breast milk.

Travoprost reaches very low plasma concentrations (AEMPS 2017, Sandoz 2016) and is undetectable in plasma 1 hour after instillation of the eye drops.

Systemic absorption should be minimized by pressing the tear duct (inner corner of the eye) with the finger for 1 to 2 minutes and administering the dose immediately after breastfeeding. (Belkin 2020, Blumen 2020, AEMPS 2017, Méndez 2012)

The small dose and poor plasma absorption of most topical ophthalmological preparations make it unlikely that significant amounts will transfer into breastmilk. 

Several medical societies and expert authors consider the use of this medication possible during breastfeeding. (Kumari 2021, Briggs 2015)

 

Alternatives

We do not have alternatives for Travoprost since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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José María Paricio, founder of e-lactancia.
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Other names

Travoprost in other languages or writings:

Group

Travoprost belongs to this group or family:

Tradenames

Main tradenames from several countries containing Travoprost in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 501 daltons
Protein Binding 80 %
pKa 13.95 -
Tmax 0.5 hours
T½ 0.25 - 1.4 hours

References

  1. Kumari R, Saha BC, Onkar A, Ambasta A, Kumari A. Management of glaucoma in pregnancy - balancing safety with efficacy. Ther Adv Ophthalmol. 2021 Jun 28;13:25158414211022876. Abstract
  2. Belkin A, Chen T, DeOliveria AR, Johnson SM, Ramulu PY, Buys YM; American Glaucoma Society and the Canadian Glaucoma Society.. A Practical Guide to the Pregnant and Breastfeeding Patient with Glaucoma. Ophthalmol Glaucoma. 2020 Mar - Apr;3(2):79-89. Abstract
  3. Blumen-Ohana E, Sellem E. [Pregnancy & glaucoma: SFO-SFG recommendations]. J Fr Ophtalmol. 2020 Jan;43(1):63-66. Abstract
  4. AEMPS. Travoprost. Ficha técnica. 2017 Full text (in our servers)
  5. Sandoz. Travoprost. Drug Summary. 2016 Full text (in our servers)
  6. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  7. Méndez-Hernández C. Uso de fármacos antiglaucomatosos durante el embarazo y lactancia. [Use of glaucoma medications during pregnancy and breastfeeding]. Arch Soc Esp Oftalmol. 2012 Dec;87(12):389-91. Abstract

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