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Non-steroidal derivative of triphenylethylene that binds to estrogen receptors and has potent anti-estrogenic properties, similar to those of tamoxifen. It is used as antineoplastic hormonal therapy in the treatment of hormone-dependent metastatic breast cancer in post-menopausal patients. Oral administration.
At the date of the last update, there was no published data available on its excretion in human milk.
Although its pharmacokinetic data (large volume of distribution, moderately high molecular weight and very high percentage of protein binding) make it unlikely for it to pass into the mothers’ milk in a clinically significant quantity, its long elimination half-life (EMA 2006) could favor it.
Breastfeeding is practically impossible, since before breastfeeding again after the last administration of toremifene, it would be necessary to wait 5 half-lives (25 days) for 97% of it to be eliminated from the body. Meanwhile, the milk would have to be expressed and discarded regularly to maintain production.