Last update Oct. 17, 2016
Antimuscarinic agent with atropine-like action.
At latest update no published data on excretion into breast milk were found.
A high plasma protein-binding capacity makes it unlikely its passage into breast milk.
Its low oral bioavailability hinders the passage from ingested milk towards the infant’s plasma, except in preterm babies and immediate neonatal period, which may show an increased intestinal permeability. There are few poor metabolizers (CYP2D6 deficient) who may exhibit increasing oral bioavailability to 66%
Take as smallest dose as possible and avoid long-term use since anticholinergics can reduce milk production.
Monitoring anticholinergic symptoms in infants (dry mouth, constipation ..) is warranted.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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