Last update Dec. 28, 2023

Tioconazole

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Tioconazole is an imidazole antifungal used to treat vulvovaginal candidiasis as well as superficial candidiasis, dermatophytosis and pityriasis versicolor. Topical cutaneous or vaginal administration.

At the time of the last update, we found no published data on its excretion in breast milk.

Systemic absorption through the skin or vagina is negligible (Hale, Mactal 2001, Houang 1985), making passage of significant amount into breast milk unlikely.

Do not apply on nipple-areola or wash off before breast-feeding.

Alternatives

  • Clotrimazole ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Miconazole ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Tioconazole in other languages or writings:

Tradenames

Main tradenames from several countries containing Tioconazole in its composition:

  • Amplogin™. Contains other elements than Tioconazole in its composition
  • Cartrax™. Contains other elements than Tioconazole in its composition
  • Fasigyn VT™. Contains other elements than Tioconazole in its composition
  • Gynben™. Contains other elements than Tioconazole in its composition
  • Gynecure
  • Gyno-Trosyd
  • Gynomax™. Contains other elements than Tioconazole in its composition
  • Honguil
  • Infester
  • Lakafin
  • Niofen
  • Seczol (Brazil)™. Contains other elements than Tioconazole in its composition
  • Sernax
  • Takil™. Contains other elements than Tioconazole in its composition
  • Telset
  • Terbul
  • Tinin™. Contains other elements than Tioconazole in its composition
  • Tiomicol
  • Tiotrax™. Contains other elements than Tioconazole in its composition
  • Tralen
  • Travogyn™. Contains other elements than Tioconazole in its composition
  • Trosid
  • Trosyd
  • Vagistat
  • Vulnagen™. Contains other elements than Tioconazole in its composition

Pharmacokinetics

Variable Value Unit
Oral Bioavail. cutan: 2.9. Vaginal: ≈ 0 %
Molecular weight 388 daltons

References

  1. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  2. Mactal-Haaf C, Hoffman M, Kuchta A. Use of anti-infective agents during lactation, Part 3: Antivirals, antifungals, and urinary antiseptics. J Hum Lact. 2001 Abstract
  3. Houang ET, Lawrence AG. Systemic absorption and persistence of tioconazole in vaginal fluid after insertion of a single 300-mg tioconazole ovule. Antimicrob Agents Chemother. 1985 Jun;27(6):964-5. Abstract Full text (link to original source)

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