Last update Sept. 4, 2021

Ticlopidine Hydrochloride

Limited compatibility

Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.

Platelet antiaggregant indicated in the prevention and treatment of thromboembolic disorders.
Oral administration in two daily doses.

At the date of the last update we did not find any published data on its excretion in breast milk.

Its very high percentage of plasma protein binding makes it difficult excretion in breast milk in significant quantities, but its long elimination half-life would facilitate it.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable (Hale, Serrano 2015, Briggs 2015, Schaefer 2015), especially during the neonatal period and in the event of prematurity.

Alternatives

  • Aspirin (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Clopidogrel (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Dipyridamole (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Ticlopidine Hydrochloride in other languages or writings:

Group

Ticlopidine Hydrochloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Ticlopidine Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 90 %
Molecular weight 264 daltons
Protein Binding 98 %
Tmax 3 hours
T½ 30 - 50 (1 dos: 8-20) hours

References

  1. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  2. AEMPS. Ticlopidina. Ficha técnica. 2021 Full text (in our servers)
  3. Serrano Aguayo P, García de Quirós Muñoz JM, Bretón Lesmes I, Cózar León MV. Tratamiento de enfermedades endocrinológicas durante la lactancia. [Endocrinologic diseases management during breastfeeding.] Med Clin (Barc). 2015 Jan 20;144(2):73-9. Abstract
  4. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  5. Schaefer C, Peters P, Miller RK. Drugs During Pregnancy and Lactation. Treatment options and risk assessment. Elsevier, Third Edition. 2015
  6. Mylan Ph. Ticlopidine Drug summary. 2011 Full text (in our servers)

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