Last update Feb. 6, 2022

Tiagabine Hydrochloride

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Anticonvulsant indicated in the treatment of epilepsy. Oral administration in one or two daily doses.

Since the last update we have not found published data on its excretion in breastmilk.

Their very high percentage of protein binding and large volume of distribution (Jacob 2016) make it highly unlikely that significant quantities will pass into breast milk.

No problems were reported in two infants whose mothers were taking it. (Tomson 2007, Neppe 2000)

Expert authors consider the use of monoclonal antibodies to be safe or very probably safe during breastfeeding. (Cabo 2019, Davanzo 2013)

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable (Bar-Oz 2000), especially during the neonatal period and in the event of prematurity.

 

Alternatives

  • Carbamazepine (Safe product and/or breastfeeding is the best option.)
  • Gabapentin (Safe product and/or breastfeeding is the best option.)
  • Lamotrigine (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Valproate, Valproic Acid (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Tiagabine Hydrochloride in other languages or writings:

Group

Tiagabine Hydrochloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Tiagabine Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 90 %
Molecular weight 412 daltons
Protein Binding 96 %
VD 1 - 1.3 l/Kg
pKa 4.14 -
Tmax 1 hours
T½ 7 - 9 hours

References

  1. Cabo-Lopez I, Canneti B, Puy-Nunez A. Epilepsia y lactancia materna: del mito a la realidad. [Epilepsy and breastfeeding: from myth to reality]. Rev Neurol. 2019 Jul 16;69(2):68-76. Abstract
  2. Jacob S, Nair AB. An Updated Overview on Therapeutic Drug Monitoring of Recent Antiepileptic Drugs. Drugs R D. 2016 Abstract Full text (link to original source) Full text (in our servers)
  3. Veiby G, Bjørk M, Engelsen BA, Gilhus NE. Epilepsy and recommendations for breastfeeding. Seizure. 2015 May;28:57-65. Abstract Full text (link to original source)
  4. Davanzo R, Dal Bo S, Bua J, Copertino M, Zanelli E, Matarazzo L. Antiepileptic drugs and breastfeeding. Ital J Pediatr. 2013 Abstract Full text (link to original source) Full text (in our servers)
  5. Tomson T, Palm R, Källén K, Ben-Menachem E, Söderfeldt B, Danielsson B, Johansson R, Luef G, Ohman I. Pharmacokinetics of levetiracetam during pregnancy, delivery, in the neonatal period, and lactation. Epilepsia. 2007 Jun;48(6):1111-6. Epub 2007 Mar 22. Abstract Full text (link to original source) Full text (in our servers)
  6. Bar-Oz B, Nulman I, Koren G, Ito S. Anticonvulsants and breast feeding: a critical review. Paediatr Drugs. 2000 Mar-Apr;2(2):113-26. Review. Abstract
  7. Neppe VM. Successful tiagabine monotherapy during pregnancy and lactation: clinical and serum data. Epilepsia 2000;41 (Suppl 7):200-201. Abstract.-Poster 3104. doi:10.1111/j.1528-1157.2000.tb01727.x Full text (link to original source) Full text (in our servers)

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