Last update Feb. 5, 2022

Thyrotropin Alfa

High Risk

Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment.

Recombinant glycoprotein analog of natural human thyroid-stimulating hormone (TSH). It is used in the diagnosis (with or without administration of radioactive iodine, 131I ) and in the treatment (with administration of 131I ) of well-differentiated thyroid cancer.

Since the last update we have not found published data on its excretion in breastmilk.

Its very high molecular weight make it highly unlikely that significant quantities will pass into breast milk. In case of maternal hypothyroidism with very high plasma levels of TSH, the amount of TSH found in milk was insignificant. (Robinson 1994)

Due to its protein nature, it deteriorates in the gastrointestinal tract, not being absorbed. Its null oral bioavailability makes it difficult for it to pass to the infant plasma from ingested breast milk, except in premature infants and in the immediate neonatal period in which there may be greater intestinal permeability.

Thyrotropin by itself is compatible with breastfeeding, but not if it is accompanied by the administration of Iodine-131.


See below the information of this related product:

  • Iodine-131 ( Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment.)

Alternatives

We do not have alternatives for Thyrotropin Alfa.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Thyrotropin Alfa is also known as


Thyrotropin Alfa in other languages or writings:

Group

Thyrotropin Alfa belongs to this group or family:

Tradenames

Main tradenames from several countries containing Thyrotropin Alfa in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 30.000 daltons
Tmax 13 ± 8 (3 - 24) hours
22 ± 9 hours

References

  1. Sanofi. Thyrotropin alfa (Thyrogen). Drug Summary 2016 Full text (in our servers)
  2. EMA. Tirotropina alfa (Thyrogen). Ficha técnica. 2010 Full text (in our servers)
  3. Robinson P, Hoad K. Thyrotropin in human breast milk. Aust N Z J Med. 1994 Feb;24(1):68. No abstract available. Abstract

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