Last update June 25, 2022

Thiothixene. Tiotixene

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

It is a typical, first generation antipsychotic with general properties similar to those of chlorpromazine, that is used for the treatment of schizophrenia and other psychoses. Oral or intramuscular administration in two or three daily doses.

No data on transfer into breastmilk are available.

Its high percentage of protein binding and moderately high molecular weight make it unlikely that significant quantities will pass into breast milk.

Product with very few bibliographical references and marketed in few countries.

Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable (Parikh 2014, Klinger 2013), especially during the neonatal period and in cases of prematurity.


See below the information of this related product:

Alternatives

  • Flupentixol (Safe substance and/or breastfeeding is the best option.)
  • Haloperidol (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Olanzapine (Safe substance and/or breastfeeding is the best option.)
  • Quetiapine Fumarate (Safe substance and/or breastfeeding is the best option.)
  • Zuclopenthixol (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Thiothixene. Tiotixene in other languages or writings:

Groups

Thiothixene. Tiotixene belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Thiothixene. Tiotixene in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 444 daltons
Protein Binding 90 %
Tmax 1 - 3 hours
10 - 20 hours

References

  1. Parikh T, Goyal D, Scarff JR, Lippmann S. Antipsychotic drugs and safety concerns for breast-feeding infants. South Med J. 2014 Abstract
  2. Klinger G, Stahl B, Fusar-Poli P, Merlob P. Antipsychotic drugs and breastfeeding. Pediatr Endocrinol Rev. 2013 Mar-Apr;10(3):308-17. Review. Abstract

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