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Pro-kinetic and selective agonist drug of 5-HT4 receptor of serotonin that may enhance bowel and colon motility. Indicated for treatment of irritable colon syndrome with predominant constipation. Oral administration twice daily.
At the time of the last update, we found no published data on its excretion in breast milk.
Its pharmacokinetic data (very large volume of distribution, moderately high molecular weight and high percentage of binding to plasma proteins) make it unlikely to pass into breast milk in clinically significant quantities.
Its low oral bioavailability makes it difficult to pass into infant plasma from ingested breast milk, except in premature infants and the immediate neonatal period where there may be greater intestinal permeability.
It has been withdrawn from most countries due to an apparent high incidence of cardiovascular ischemic events. (Sayuk 2023)