Last update March 31, 2019
Very Low Risk
We do not have alternatives for Technetium 99m Exametazime (HMPAO) since it is relatively safe.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Technetium 99m Exametazime (HMPAO) is also known as
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e-lactancia is a resource recommended by Asociación Pro Lactancia Materna (APROLAM) of Mexico
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
Metastable Technetium 99 (99mTc) is a radioactive isotope that emits gamma radiation. Its radioactive decay half-life is 6.0 hours.
After radioactive labelling with a sodium pertechnetate (Tc 99m) solution, the exametazime (Tc 99m) test solution obtained is used in single photon emission computed tomography (SPECT) for the diagnosis of brain conditions, hidden foci of infection and extension of inflammatory bowel disease by leukocyte labelling.
0.1% of the administered dose is excreted in breast milk (Leide 2016, Liepe 2016).
Breastfeeding interruption or close contact avoidance times are calculated so that the infant is not exposed to more than 1 millisievert (1 mSv = 0.1 rem) of radiation (ARSAC 2019, US.NCR 2016, ICRP 2008, Stabin 2000). An adult receives between 5 and 10 mSv annually from environmental radiation.
The main regulatory agencies which manage radioactive substances and experts consider that breastfeeding can be resumed immediately after a diagnostic test with Tc 99m exametazime (ARSAC 2019 p51, ICRP 2008 p163, Marshall 1996).
Some agencies (ARSAC 2019, ICRP 2008) consider it more prudent to discontinue breastfeeding for about 4 hours, expressing breast milk and instead offering milk previously expressed and stored in a refrigerator prior to testing.
Milk expressed after the diagnostic test can be frozen and used after 10 radioactive half lives: 10 x 6.0 = 60 hours = 3 days (Hale 2017, p.2019).
Close contact with the infant need not be avoided (Mountford 1999).
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