Last update Aug. 31, 2022

سيفادروكسيل

Compatible

Safe product and/or breastfeeding is the best option.

It is a First generation Cephalosporin.

Like other Cephalosporins, Cefadroxil is excreted into the breast milk in clinically non-significant amounts. (Matsuda 1984, Kafetzis 1981, Takase 1979 )

Although rare, the possibility of transient gastroenteritis due to alteration of the intestinal flora in infants whose mothers take antibiotics should be taken into account. (Ito 1993)

Expert authors consider the use of this medication to be compatible during breastfeeding (Hale, LactMed, Briggs 2015, Bar-Oz 2003, Fulton 1992). American Academy of Pediatrics: medication usually compatible with breastfeeding.(AAP 2001)

Alternatives

We do not have alternatives for سيفادروكسيل since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

سيفادروكسيل is Cefadroxil in Arabic.

Is written in other languages:

Group

سيفادروكسيل belongs to this group or family:

Tradenames

Main tradenames from several countries containing سيفادروكسيل in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 381 daltons
Protein Binding 28 %
VD 0.3 l/Kg
pKa 3.25 -
Tmax 1 - 2 hours
1.5 hours
M/P ratio 0.01 - 0.1 -
Theoretical Dose 0.09 - 0.36 mg/Kg/d
Relative Dose 0.3 - 2.2 %
Ped.Relat.Dose 0.3 - 1.2 %

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  3. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  4. Bar-Oz B, Bulkowstein M, Benyamini L, Greenberg R, Soriano I, Zimmerman D, Bortnik O, Berkovitch M. Use of antibiotic and analgesic drugs during lactation. Drug Saf. 2003 Abstract
  5. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  6. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  7. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract
  8. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy Perinatol. 1984;5(2):57-60. Abstract
  9. Kafetzis DA, Siafas CA, Georgakopoulos PA, Papadatos CJ. Passage of cephalosporins and amoxicillin into the breast milk. Acta Paediatr Scand. 1981 Abstract
  10. Takase Z, Shirafuji H, Uchida M. Clinical and laboratory studies of cefaclor in the field of obstetrics and gynecology. Chemotherapy (Tokyo). 1979;27(Suppl 7):666-72. 1979

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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America

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