Last update Jan. 29, 2022


Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Sulfonamide with properties similar to those of sulfamethoxazole. Used topically (dermatological and vaginal) for the treatment of susceptible infections.

Since the last update we have not found any published data on its excretion in breast milk.

The small dose and poor plasma uptake of most topical dermatological preparations make it very unlikely that significant amounts will pass into breast milk.

Vaginally it can be absorbed in variable quantity (PDR 2019). Do not use vaginally during the neonatal period and in deficit of glucose-6-phosphate dehydrogenase. (AEHH2012)

Sulphamides are excreted in small amounts in breast milk: 6 to 94 micrograms/ml, 1.6% of the total dose. (Briggs 2015)

Reports of adverse effects are rare (Briggs 2015). Avoid in suspected glucose-6-phosphate dehydrogenase deficiency.  

Due to the greater toxicity than that of other antimicrobials and their high acquired resistance, the use of sulfonamides is currently very scarce. (Pérez 2003)

Do not apply on the breast so as to avoid its ingestion by the infant; alternatively clean before breastfeeding.

See below the information of this related product:


  • Chlorhexidine (Safe substance and/or breastfeeding is the best option.)
  • Fluconazole (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Sulfanilamide is also known as

Sulfanilamide in other languages or writings:


Main tradenames from several countries containing Sulfanilamide in its composition:


Variable Value Unit
Oral Bioavail. ≈ 0 %
Molecular weight 172 daltons


  1. PDR online Sulfanilamide (AVC Vaginal Cream 15%). Drug Summary. 2019 Full text (link to original source) Full text (in our servers)
  2. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  3. AEHH: Asociación Española de Hematología y Hemoterapia. EL DEFICIT DE GLUCOSA-6-FOSFATO DESHIDROGENASA (G6PD). EL FAVISMO AEHH 2012 Full text (link to original source) Full text (in our servers)
  4. Pérez-Trallero E, Iglesias L. Tetraciclinas, sulfamidas y metronidazol. [Tetracyclines, sulfonamides and metronidazole]. Enferm Infecc Microbiol Clin. 2003 Nov;21(9):520-8; quiz 529, 533. Review. Spanish. Abstract Full text (link to original source)

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