Last update Jan. 29, 2022

Sulfadiazine; Sulphadiazine

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

It is a short-acting sulfonamide with uses similar to sulfamethoxazole. Together with pyrimethamine it is used in the treatment of toxoplasmosis. Oral administration every 4 - 6 hours.

Since the last update we have not found published data on its excretion in breastmilk.

Sulphamides are excreted in small amounts in breast milk: 6 to 94 micrograms/ml, 1.6% of the total dose. (Briggs 2015)

Reports of adverse effects are rare (Briggs 2015). Avoid in suspected glucose-6-phosphate dehydrogenase deficiency.  

Due to the greater toxicity than that of other antimicrobials and their high acquired resistance, the use of sulfonamides is currently very scarce. (Pérez 2003)


Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Sulfadiazine; Sulphadiazine is also known as

Sulfadiazine; Sulphadiazine in other languages or writings:


Main tradenames from several countries containing Sulfadiazine; Sulphadiazine in its composition:


Variable Value Unit
Oral Bioavail. 85 %
Molecular weight 250 daltons
Protein Binding 55 %
pKa 6.99 -
Tmax 3 - 6 hours
10 (7 - 17) hours
M/P ratio 1 -


  1. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  2. Pérez-Trallero E, Iglesias L. Tetraciclinas, sulfamidas y metronidazol. [Tetracyclines, sulfonamides and metronidazole]. Enferm Infecc Microbiol Clin. 2003 Nov;21(9):520-8; quiz 529, 533. Review. Spanish. Abstract Full text (link to original source)

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