Last update Aug. 12, 2014

Streptomycin

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Aminoglycosides are poorly absorbed by the intestine. Large doses may affect intestinal flora. Be aware of the possibility of false negative results of bacterial cultures when the mother is on antibiotics.

Alternatives

We do not have alternatives for Streptomycin since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Group

Streptomycin belongs to this group or family:

Tradenames

Main tradenames from several countries containing Streptomycin in its composition:

  • Estreptocarbocaftiazol™. Contains other elements than Streptomycin in its composition
  • Gemipasmol™. Contains other elements than Streptomycin in its composition

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Baja - Low %
Molecular weight 582 daltons
Protein Binding 33 %
Tmax 2 hours
T½ 5.3 hours
M/P ratio 1 -
Theoretical Dose 0.1 mg/Kg/d
Relative Dose 0.6 %
Ped.Relat.Dose 0.5 %

References

  1. Drobac PC, del Castillo H, Sweetland A, Anca G, Joseph JK, Furin J, Shin S. Treatment of multidrug-resistant tuberculosis during pregnancy: long-term follow-up of 6 children with intrauterine exposure to second-line agents. Clin Infect Dis. 2005 Jun 1;40(11):1689-92. Epub 2005 Apr 18. Abstract Full text (link to original source) Full text (in our servers)
  2. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  3. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  4. Chin KG, McPherson CE 3rd, Hoffman M, Kuchta A, Mactal-Haaf C. Use of anti-infective agents during lactation: Part 2--Aminoglycosides, macrolides, quinolones, sulfonamides, trimethoprim, tetracyclines, chloramphenicol, clindamycin, and metronidazole. J Hum Lact. 2001 Feb;17(1):54-65. Abstract
  5. Tran JH, Montakantikul P. The safety of antituberculosis medications during breastfeeding. J Hum Lact. 1998 Dec;14(4):337-40. Review. Abstract

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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America

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