Last update July 31, 2017

Streptokinase

Compatible

Safe product and/or breastfeeding is the best option.

A fibrinolytic enzyme obtained from the culture of streptococcus strains. Administered intravenously to treat acute myocardial infarction, pulmonary embolism and deep-vein thrombosis.

It is also used topically with streptokinase to remove clots or purulent matter from wounds or cavities (pleura, bladder).

There is no scientific support for the effectiveness of its oral administration, since there is evidence of its lack of oral absorption and absence of fibrinolytic properties when taken orally (Oliven 1981, Vonmoos 1979).

Since the last update we have not found published data on its excretion in breast milk, but given the lack of absorption when taken orally, high molecular weight and very rapid elimination when administered intravenously, it is unlikely to be excreted in breast milk in significant quantities which furthermore would not be absorbed in the infant's intestine.

Alternatives

We do not have alternatives for Streptokinase since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.
DONATE NOW

Other names

Streptokinase is also known as


Streptokinase in other languages or writings:

Group

Streptokinase belongs to this group or family:

Tradenames

Main tradenames from several countries containing Streptokinase in its composition:

List of 12 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Baja - Low %
Molecular weight 47.400 daltons
VD 1 l/Kg
T½ 0.3 - 1.2 hours

References

  1. Gemmill JD, Hogg KJ, Burns JM, Rae AP, Dunn FG, Fears R, Ferres H, Standring R, Greenwood H, Pierce D, et al. A comparison of the pharmacokinetic properties of streptokinase and anistreplase in acute myocardial infarction. Br J Clin Pharmacol. 1991 Abstract
  2. Grierson DS, Bjornsson TD. Pharmacokinetics of streptokinase in patients based on amidolytic activator complex activity. Clin Pharmacol Ther. 1987 Abstract
  3. Oliven A, Gidron E. Orally and rectally administered streptokinase. Investigation of its absorption and activity. Pharmacology. 1981 Abstract
  4. Vonmoos PL, Straub PW. [Absorption and hematologic effect of streptokinase-streptodornase (varidase) after intracavital or oral administration]. Schweiz Med Wochenschr. 1979 Abstract

Total visits

12,551

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at elactancia.org@gmail.com

e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM