Last update Oct. 23, 2024

Sodium Stibogluconate

Compatible

Safe product and/or breastfeeding is the best option.

Pentavalent antimony compounds, such as sodium stibogluconate or meglumine antimoniate, are used as first-line treatment for most forms of leishmaniasis: Intramuscular, intravenous or intralesional administration. 

Excreted in breast milk in a clinically insignificant amount. (Berman 1989)

Its low oral bioavailability makes it difficult to pass into infant plasma from ingested breast milk, except in premature infants and the immediate neonatal period where there may be greater intestinal permeability.

Authorized for use in pediatrics, even in small infants.

A 4-year-old breastfed girl had severe perioral and oral lesions due to maternal nipple-areola lesions at 3 months of age. She was successfully treated with sodium stibogluconate and meglumine antimoniate. (Costa 1988)

American Academy of Pediatrics: antimony compounds are a medication that is generally compatible with breastfeeding. (AAP 2001)

Alternatives

We do not have alternatives for Sodium Stibogluconate since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Sodium Stibogluconate is also known as


Sodium Stibogluconate in other languages or writings:

Group

Sodium Stibogluconate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Sodium Stibogluconate in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. baja / poor %
Molecular weight 908 daltons
T½ leche / milk: 6 hours
Theoretical Dose 0.3 mg/Kg/d
Relative Dose 1.6 %

References

  1. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  2. Berman JD, Melby PC, Neva FA. Concentration of Pentostam in human breast milk. Trans R Soc Trop Med Hyg. 1989 Nov-Dec;83(6):784-5. No abstract available. Abstract
  3. Costa JM, Vale KC, França F, Lago EL, Magalhães AV, Marsden PD, Sampaio RN. LEISHMANIOSE CAUSADA POR LEISHMANIA VIANNIA BRAZILIENSIS. (Lvb) UM CASO DE EVOLUÇÃO ATÍPICA. [Leishmaniasis caused by Leishmania viannia braziliensis (Lvb). A case of atypical course]. Rev Soc Bras Med Trop. 1988 Apr-Jun;21(2):71-3. Portuguese. No abstract available. Abstract Full text (link to original source)

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