Last update Sept. 14, 2022

στιλβοεστρόλη

Very High Risk

Very unsafe. Contraindicated. Use of an alternative or cessation of breastfeeding. Read the Comment.

Diethylstilbestrol (DES) is a synthetic nonsteroidal estrogen that has been used to palliate breast and prostate cancer. It has been used in the past to prevent miscarriage or premature labor, to suppress postpartum lactation, and to prevent or treat breast engorgement.

Since the last update we have not found published data on its excretion in breastmilk.

It is a carcinogenic, withdrawn from the market in many countries. DES exposure during pregnancy has been associated with an increased risk of breast cancer in mothers and with an increased lifetime risk of cervicovaginal cancer in daughters exposed in utero. (Tournaire 2014, Troisi 2007, Giusti 1995, Clark 1979)

Alternatives

We do not have alternatives for στιλβοεστρόλη.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

στιλβοεστρόλη is Diethylstilbestrol in Greek.

Is written in other languages:

στιλβοεστρόλη is also known as

Tradenames

Main tradenames from several countries containing στιλβοεστρόλη in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 268 daltons
pKa 8.63 -

References

  1. Tournaire M, Epelboin S, Devouche E. [Diethylstilbestrol story]. Therapie. 2014 Jan-Feb;69(1):101-14. Abstract
  2. Troisi R, Hatch EE, Titus-Ernstoff L, Hyer M, Palmer JR, Robboy SJ, Strohsnitter WC, Kaufman R, Herbst AL, Hoover RN. Cancer risk in women prenatally exposed to diethylstilbestrol. Int J Cancer. 2007 Jul 15;121(2):356-60. Abstract
  3. Giusti RM, Iwamoto K, Hatch EE. Diethylstilbestrol revisited: a review of the long-term health effects. Ann Intern Med. 1995 May 15;122(10):778-88. Review. Abstract
  4. Clark LC, Portier KM. Diethylstilbestrol and the risk of cancer. N Engl J Med. 1979 Feb 1;300(5):263-4. Abstract

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