Last update June 10, 2018

セルタコナゾール硝酸塩

Compatible

Safe product and/or breastfeeding is the best option.

An imidazole antifungal agent used topically as a skin cream or in the form of vaginal ovules.

Since the last update date we have not found published data on its excretion in breastmilk.

The mean plasma concentration after the application of 300 mg of vaginal sertaconazole was 1.79 ± 0.70 micrograms/L (Wang 2009).

Its insignificant or zero systemic absorption through vaginal mucosa or skin (Croxtall 2009, Wang 2009, Susilo 2006, Farré 1992) and its high plasma protein binding makes transfer to milk in significant quantities unlikely.

You should wash your hands well after application.

Do not apply on breast-nipple-areola or clean before breastfeeding.

Alternatives

We do not have alternatives for セルタコナゾール硝酸塩 since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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José María Paricio, founder of e-lactancia.
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Other names

セルタコナゾール硝酸塩 is Sertaconazole Nitrate in Japanese.

Is written in other languages:

セルタコナゾール硝酸塩 is also known as

Groups

セルタコナゾール硝酸塩 belongs to these groups or families:

Tradenames

Main tradenames from several countries containing セルタコナゾール硝酸塩 in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. baja - poor %
Molecular weight 501 daltons
Protein Binding 99 %
pKa 6.77 -
Tmax 7.0 ± 1.5 (vaginal) hours
T½ 20.3 ± 9.1 hours

References

  1. Croxtall JD, Plosker GL. Sertaconazole: a review of its use in the management of superficial mycoses in dermatology and gynaecology. Drugs. 2009 Abstract
  2. Wang Y, Pang L, Wu M, Ou N. A validated LC-MS/MS method for determination of sertaconazole nitrate in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Abstract
  3. Susilo R, Korting HC, Greb W, Strauss UP. Nail penetration of sertaconazole with a sertaconazole-containing nail patch formulation. Am J Clin Dermatol. 2006 Abstract
  4. Farré M, Ugena B, Badenas JM, Márquez M, Roset P, Ortiz JA. Pharmacokinetics and tolerance of sertaconazole in man after repeated percutaneous administration. Arzneimittelforschung. 1992 Abstract

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