Last update July 20, 2017

Salmeterol

Compatible

Safe substance and/or breastfeeding is the best option.

Long-acting bronchodilator.



At latest update no published data on excretion into breastmilk were found.



Because of a high plasma protein-binding capacity and very low or undetectable plasma concentrations observed after inhalation (Cazzola 2002, AEMPS 2012) the excretion into breastmilk in significant amounts is unlikely.

Its low oral bioavailability would hamper the pass to the infant’s plasma through the breastmilk ingested.



Experts and scientific societies consider the use of Salmeterol during breastfeeding as devoid of risk for the infant (Ellsworth 1994, McDonald 1996, Nelson 2001, National Asthma Education 2004).



Terbutaline (see specific info), a molecule related to the same group of drugs, is excreted in non-significant amounts into breastmilk.


See below the information of this related product:

Alternatives

We do not have alternatives for Salmeterol since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Salmeterol is also known as


Salmeterol in other languages or writings:

Group

Salmeterol belongs to this group or family:

Tradenames

Main tradenames from several countries containing Salmeterol in its composition:

List of 46 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. baja - poor %
Molecular weight 604 daltons
Protein Binding 98 %
Tmax 0.1 - 0.75 hours
T½ 5.5 hours
M/P ratio 1 -

References

  1. Chambers CD, Krishnan JA, Alba L, Albano JD, Bryant AS, Carver M, Cohen LS, Gorodetsky E, Hernandez-Diaz S, Honein MA, Jones BL, Murray RK, Namazy JA, Sahin L, Spong CY, Vasisht KP, Watt K, Wurst KE, Yao L, Schatz M. The safety of asthma medications during pregnancy and lactation: Clinical management and research priorities. J Allergy Clin Immunol. 2021 Jun;147(6):2009-2020. Abstract Full text (link to original source)
  2. PDR.net Fluticasone-Salmeterol Drug Summary 2013 Full text (in our servers)
  3. AEMPS. Salmeterol. Ficha técnica. 2012 Full text (in our servers)
  4. Chen LH, Zeind C, Mackell S, LaPointe T, Mutsch M, Wilson ME. Breastfeeding travelers: precautions and recommendations. J Travel Med. 2010 Jan-Feb;17(1):32-47. Abstract Full text (link to original source) Full text (in our servers)
  5. Nice FJ, De Eugenio D, Dimino TA, Freeny IC, Rovnack MB, Gromelski JS. Medications and Breast-Feeding: A Guide for Pharmacists, Pharmacy Technicians, and Other Healthcare Professionals. Part I. J Pharm Technol 2004;20:17-27. doi: 10.1177/875512250402000106.
  6. National Asthma Education and Prevention Program Asthma and Pregnancy Working Group. Managing asthma during pregnancy: recommendations for pharmacologic treatment-2004 update. 2004;1-57. None 2004 Full text (link to original source) Full text (in our servers)
  7. Cazzola M, Testi R, Matera MG. Clinical pharmacokinetics of salmeterol. Clin Pharmacokinet. 2002 Abstract
  8. Nelson-Piercy C. Asthma in pregnancy. Thorax. 2001 Abstract Full text (link to original source) Full text (in our servers)
  9. Ellsworth A. Pharmacotherapy of asthma while breastfeeding. J Hum Lact. 1994 Abstract

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