Last update Feb. 3, 2022

Saccharomyces boulardii


Safe substance and/or breastfeeding is the best option.

A yeast strain isolated from various tropical fruits. Related to saccharomyces cerevisiae or brewer's yeast. Unicellular fungus which produces lactic acid used as a probiotic to regenerate the intestinal flora in case of infectious diarrhea or diarrhea associated with taking antibiotics.

Since the last update we have not found published data on its excretion in breast milk, but due to its lack of intestinal absorption it is considered safe during breastfeeding.

There is controversy about its effectiveness (Poncelet 2021, Williams 2010) and although it is considered a safe product in immunocompetent people, there have been cases of widespread infection by the fungus itself in the absence of immune deficiency. (Martin 2017)

Administration of probiotics and other live organisms is contraindicated in immunocompromised persons. (Poncelet 2021, Williams 2010)

See below the information of these related products:

  • Brewer´s Yeast (Safe substance and/or breastfeeding is the best option.)
  • Probiotics (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)


We do not have alternatives for Saccharomyces boulardii since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.


Main tradenames from several countries containing Saccharomyces boulardii in its composition:


Variable Value Unit
Oral Bioavail. 0 %


  1. Poncelet A, Ruelle L, Konopnicki D, Miendje Deyi VY, Dauby N. Saccharomyces cerevisiae fungemia: Risk factors, outcome and links with S. boulardii-containing probiotic administration. Infect Dis Now. 2021 May;51(3):293-295. Abstract
  2. Martin IW, Tonner R, Trivedi J, Miller H, Lee R, Liang X, Rotello L, Isenbergh E, Anderson J, Perl T, Zhang SX. Saccharomyces boulardii probiotic-associated fungemia: questioning the safety of this preventive probiotic's use. Diagn Microbiol Infect Dis. 2017 Abstract
  3. Ehrhardt S, Guo N, Hinz R, Schoppen S, May J, Reiser M, Schroeder MP, Schmiedel S, Keuchel M, Reisinger EC, Langeheinecke A, de Weerth A, Schuchmann M, Schaberg T, Ligges S, Eveslage M, Hagen RM, Burchard GD, Lohse AW. Saccharomyces boulardii to Prevent Antibiotic-Associated Diarrhea: A Randomized, Double-Masked, Placebo-Controlled Trial. Open Forum Infect Dis. 2016 Abstract
  4. Hayes SR, Vargas AJ. Probiotics for the Prevention of Pediatric Antibiotic-Associated Diarrhea. Explore (NY). 2016 Abstract
  5. Szajewska H, Kołodziej M. Systematic review with meta-analysis: Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea. Aliment Pharmacol Ther. 2015 Abstract
  6. MedlinePlus. Saccharomyces boulardii. Información de salud para usted. 2015 Full text (link to original source) Full text (in our servers)
  7. MedlinePlus Saccharomyces boulardii. Trusted Health Information for You. 2015 Full text (link to original source) Full text (in our servers)
  8. Williams NT. Probiotics. Am J Health Syst Pharm. 2010 Mar 15;67(6):449-58. Abstract

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