(RS)-2-{2-[4-(p-Chloro-α-phenylbenzyl)piperazin-1-yl]ethoxy}ethanol

First-generation antihistamine, piperazine derived drug with mild sedative effect. It is used to treat anxiety, vomiting, itching and urticaria. Authorized use in young infants. Oral or intramuscular administration up to 4 times a day. It is metabolized into Cetirizine, which is compatible with breastfeeding.

At last update no relevant information concerning breastfeeding were found.

Its pharmacokinetic characteristics, high plasma protein binding and very large volume of distribution ^{(del Cuvillo 2006)},  make it very unlikely its excretion into breast milk in significant amounts.

Since it has been shown to be well tolerated by young infants for itching relief and because it is metabolized into Cetirizine, we would assume that there is a low risk for breastfeeding in short-term treatments.

Some suspected cases of non-severe sedation have been described in infants of mothers taking hydroxyzine. ^{(Soussan 2014, Ito 1993)}

Its dopaminergic effect is anti-prolactin (dopamine inhibits prolactin secretion) and may decrease milk production during the first weeks after delivery. When breastfeeding is well established, prolactin levels are not correlated with milk production (Messinis 1985).

Drowsiness and adequate feeding of the infant should be monitored ^{(Solhaug 2004)}. Co-sleeping with the baby is not recommended if this drug is being taken (UNICEF 2013, Landa 2012, ABM 2008, UNICEF 2006).

See below the information of this related product:

• Cetirizine Hydrochloride (Safe substance and/or breastfeeding is the best option.)