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An antibacterial agent that is not absorbed when taken orally, used in the treatment of traveller's diarrhoea and topically in eye and ear infections. Intramuscular and intravenous formulations are also available.
At the date of the last update, no data on its excretion in breast milk had been published.
Its pharmacokinetic data (large volume of distribution, moderately high molecular weight, high percentage of plasma protein binding and, above all, its zero oral bioavailability) make it difficult or impossible for it to pass into breast milk in clinically significant amounts.
In addition, its zero oral bioavailability prevents it from passing into the infant's plasma from ingested breast milk.