Last update Jan. 13, 2023

R06AE04

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

It is a first generation anti-histaminic and piperazine drug with a moderate sedative effect. Commercialized in association with other drugs for coughing relief and expectorant compounds. It has been used to treat hives, rhinitis, pruritus, and other allergy symptoms, and as an antiemetic. Oral administration.

At the date of the last update we did not find any published data on its excretion in breast milk.

Its high binding to plasma proteins makes it difficult to pass into breast milk.

Avoid drug associations, in general, and more during lactation.

The literature on this drug is scarce and it is sold in few countries.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.

 

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

R06AE04 is Chlorcyclizine Hydrochloride in ATC Code/s.

Is written in other languages:

Group

R06AE04 belongs to this group or family:

Tradenames

Main tradenames from several countries containing R06AE04 in its composition:

  • Ahist
  • Anervan
  • Dallergy™. Contains other elements than R06AE04 in its composition
  • Diminex Antitusigeno
  • NasOpen™. Contains other elements than R06AE04 in its composition
  • Nasotuss™. Contains other elements than R06AE04 in its composition
  • Poly-Tussin™. Contains other elements than R06AE04 in its composition
  • Poly-Tussin D™. Contains other elements than R06AE04 in its composition
  • Primatour™. Contains other elements than R06AE04 in its composition
  • Stahist AD™. Contains other elements than R06AE04 in its composition
  • Trihistan

Pharmacokinetics

Variable Value Unit
Molecular weight 337 daltons
Protein Binding 85 - 90 %
12 hours

References

  1. DRUGBANK ONLINE. DrugBank.com 2006 - Consulted on Jan. 9, 2024 Full text (link to original source)

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