Last update Aug. 18, 2021

Pyrazinamide (PZA)

Compatible

Safe product and/or breastfeeding is the best option.

Synthetic derivative of nicotinamide indicated in the treatment of tuberculosis.
Oral administration in a daily or three weekly doses.
Authorized use in pediatrics from one month of age.

It is excreted in breast milk in a clinically non-significant amount (Holdiness 1984).
No problems have been observed in infants whose mothers took it (Drobac 2005).

Various medical societies and expert consensus consider the use of this medication safe during breastfeeding (Baquero 2015, ATC 2003, CDC 2003).
WHO Essential Medicines List: compatible with breastfeeding (WHO 2002).

Alternatives

We do not have alternatives for Pyrazinamide (PZA) since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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José María Paricio, founder of e-lactancia.
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Other names

Pyrazinamide (PZA) is also known as


Pyrazinamide (PZA) in other languages or writings:

Group

Pyrazinamide (PZA) belongs to this group or family:

Tradenames

Main tradenames from several countries containing Pyrazinamide (PZA) in its composition:

List of 13 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 95 %
Molecular weight 123 daltons
Protein Binding 10 %
VD 0.8 - 1.7 l/Kg
pKa 13.1 -
Tmax 2 hours
T½ 9 - 12 hours
M/P ratio 0.04 -
Theoretical Dose 0.2 mg/Kg/d
Relative Dose 1.3 %
Ped.Relat.Dose 0.5 - 1.0 %

References

  1. Algharably EA, Kreutz R, Gundert-Remy U. Infant Exposure to Antituberculosis Drugs via Breast Milk and Assessment of Potential Adverse Effects in Breastfed Infants: Critical Review of Data. Pharmaceutics. 2023 Apr 13;15(4). pii: 1228. Abstract Full text (link to original source)
  2. Baquero-Artigao F, Mellado Peña MJ, del Rosal Rabes T, Noguera Julián A, Goncé Mellgren A, de la Calle Fernández-Miranda M, Navarro Gómez ML; Working Group on gestational, congenital, and postnatal tuberculosis, Spanish Society of Pediatric Infectious Diseases (PFIC). Guía de la Sociedad Española de Infectología Pediátrica sobre tuberculosis en la embarazada y el recién nacido (ii): profilaxis y tratamiento. [Spanish Society for Pediatric Infectious Diseases guidelines on tuberculosis in pregnant women and neonates (ii): Prophylaxis and treatment]. An Pediatr (Barc). 2015 Abstract Full text (link to original source) Full text (in our servers)
  3. Drobac PC, del Castillo H, Sweetland A, Anca G, Joseph JK, Furin J, Shin S. Treatment of multidrug-resistant tuberculosis during pregnancy: long-term follow-up of 6 children with intrauterine exposure to second-line agents. Clin Infect Dis. 2005 Jun 1;40(11):1689-92. Epub 2005 Apr 18. Abstract Full text (link to original source) Full text (in our servers)
  4. ATC. Blumberg HM, Burman WJ, Chaisson RE, Daley CL, Etkind SC, Friedman LN, Fujiwara P, Grzemska M, Hopewell PC, Iseman MD, Jasmer RM, Koppaka V, Menzies RI, O'Brien RJ, Reves RR, Reichman LB, Simone PM, Starke JR, Vernon AA; American Thoracic Society, Centers for Disease Control and Prevention and the Infectious Diseases Society. American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: treatment of tuberculosis. Am J Respir Crit Care Med. 2003 Abstract Full text (link to original source) Full text (in our servers)
  5. CDC. (American Thoracic Society); CDC; Infectious Diseases Society of America. Treatment of tuberculosis. MMWR Recomm Rep. 2003 Abstract Full text (link to original source) Full text (in our servers)
  6. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  7. Holdiness MR. Antituberculosis drugs and breast-feeding. Arch Intern Med. 1984 Abstract Full text (link to original source)

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