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Prothrombin complex concentrates are plasma-derived factor IX preparations that are rich in other coagulation factors: factor II, factor VII, and factor X. They are used in bleeding due to deficiencies of factors II, VII, IX, and X, congenital or by treatment or overdose with vitamin K antagonists (e.g. warfarin) and in the treatment of patients with haemophilia A who have antibodies against factor VIII. intravenous administration.
Since the last update we have not found published data on its excretion in breastmilk.
The very high molecular weight of its different components make it highly unlikely that significant quantities will pass into breast milk.
Due to its protein nature, it is inactivated in the gastrointestinal tract, and is not absorbed, (it has virtually no oral bioavailability), which hinders or prevents its transfer from breastmilk to infant, except in premature babies and the immediate neonatal period, when there may be greater intestinal permeability.
Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs: compatible with Breastfeeding. (WHO 2002)