Last update June 10, 2018

Propyphenazone

Very High Risk

Very unsafe. Contraindicated. Use of an alternative or cessation of breastfeeding. Read the Comment.

An analgesic derived from pyrazolone, inhibitor of prostaglandin synthesis by inhibiting cyclooxygenase.
Administered orally and rectally.

Since the last update date we have not found published data on its excretion in breastmilk.

Severe hemolytic anemia has been reported in a newborn whose mother was taking it (Frei 1985).

Since 1989, it has been withdrawn from sale in many countries for having caused medullary aplasia, Lyell's syndrome and other serious side effects (Onakpoya 2018).

It is marketed in multiple preparations that combine caffeine, codeine, atropine and anti-inflammatory drugs. In general, drug combinations are not recommended and even less so during breastfeeding.

Known alternatives which are safer during breastfeeding are preferred, especially during the neonatal period and in the case of prematurity.

Alternatives

  • Diclofenac ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Ibuprofen ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Paracetamol ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Propyphenazone is also known as


Propyphenazone in other languages or writings:

Group

Propyphenazone belongs to this group or family:

Tradenames

Main tradenames from several countries containing Propyphenazone in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 90 %
Molecular weight 230 daltons
Protein Binding 10 - 20 %
VD 1.3 l/Kg
Tmax 1 - 3 hours
1 - 1.5 hours

References

  1. Onakpoya IJ, Heneghan CJ, Aronson JK. Post-marketing withdrawal of analgesic medications because of adverse drug reactions: a systematic review. Expert Opin Drug Saf. 2018 Abstract
  2. AEMPS. Saridon. Ficha técnica. 2015 Full text (in our servers)
  3. Frei H, Bühlmann U, Rudin O. [Toxic hemolytic anemia in the newborn infant following ingestion of a phenazone derivative (Cibalgin) via breast milk]. Z Geburtshilfe Perinatol. 1985 Jan-Feb;189(1):11-2. German. Abstract

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