Last update Sept. 4, 2022
1st-generation-antihistamine and phenothiazine-type drug with a strong sedative effect.
At latest update relevant published data on excretion into breast milk were not found.
Pharmacokinetic data (high volume of distribution and high plasma protein-binding capacity) would render it unlikely a significant passage into the breastmilk.
In addition, a low oral bioavailability would hinder a further passage to infant’s plasma through the ingested breastmilk, except on premature infants and immediate neonatal period when there may be an increased intestinal permeability.
It may decrease prolactin levels and interfere with milk production during the first few weeks after birth. (Pontiroli 1981, Messinis 1985)
It may be considered compatible with breastfeeding on isolated doses such as those used for pre-surgical medication or traveler's dizziness. (WHO 2002)
Avoid a repeated use as it may cause drowsiness in the infant. Avoid using it in the immediate neonatal period (first 4 to 6 weeks after birth) and in case of prematurity.
There are doubts about any association with Sudden Infant Death Syndrome (SIDS) (Kahn 1982, Stanton 1983). If used, follow-up the infant for drowsiness and feeding issues.
Bed-sharing with the baby is not recommended if drugs are used due to increased risk of suffocation or sudden infant death. (ABM 2020 y 2008, UNICEF 2018, 2017, 2014 y 2013, Landa 2012, UNICEF 2006)
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.
Thank you for helping to protect and promote breastfeeding.
e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM