Last update Nov. 8, 2022

Prebiotics

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Prebiotics are non-digestible and non-absorbable substances that pass through the digestive system serving as food and stimulating the growth of benign intestinal microflora/microbiota, mainly bifidobacteria and lactobacilli, for the intended purpose of improving health. They are found in fruits, vegetables, legumes, cereals, nuts, milk and honey. They are complex carbohydrates, such as fiber and resistant starch. They can be non-starch polysaccharides (polymers of fructose, galactose, lactose or xylose) and oligosaccharides. Oral administration. (Cucalón 2020, Gibson 2017, Corzo 2014)

At the date of the last update, we found no published data on its excretion in breast milk.

Since by definition they are nonabsorbable (no oral bioavailability), they do not represent any problem during lactation.

Breast milk and especially colostrum contain oligosaccharides with a prebiotic effect (12 g/L and 14 g/L, respectively), which are responsible for the high content of bifidobacteria present in the feces of breastfed infants and for the reduction in the risk of necrotizing enterocolitis in premature newborns. (Nolan 2020, Wiciński 2020, Bering 2018, Corzo 2014, Bode 2015 and 2012)

Definitive evidence of many of its claimed beneficial effects is lacking. The use of prebiotics to improve health should not be a substitute for healthy nutrition and lifestyle. (Gibson 2017)

Inulin is also used intravenously as a diagnostic agent to measure glomerular filtration rate. It is rapidly eliminated by the kidney without being metabolized and its high molecular weight prevents its passage into breast milk, in addition to not being absorbable by the infant's intestine, so this indication is also compatible with breastfeeding.

 

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Group

Prebiotics belongs to this group or family:

Tradenames

Main tradenames from several countries containing Prebiotics in its composition:

  • Acidolac (Ацидолак)™. Contains other elements than Prebiotics in its composition
  • Actyfilus™. Contains other elements than Prebiotics in its composition
  • Arko Levura™. Contains other elements than Prebiotics in its composition
  • Arkolevure™. Contains other elements than Prebiotics in its composition
  • Bagovital Inmune™. Contains other elements than Prebiotics in its composition
  • Beneflora™. Contains other elements than Prebiotics in its composition
  • Breveluck (Бревелак)™. Contains other elements than Prebiotics in its composition
  • Calmora™. Contains other elements than Prebiotics in its composition
  • Culture Care™. Contains other elements than Prebiotics in its composition
  • Enterolactis Duo™. Contains other elements than Prebiotics in its composition
  • Inufix
  • Inulac
  • Lactiflora Fem™. Contains other elements than Prebiotics in its composition
  • Lero Flore™. Contains other elements than Prebiotics in its composition
  • Markofruct™. Contains other elements than Prebiotics in its composition
  • Maxi-Flore™. Contains other elements than Prebiotics in its composition
  • Opefera (Опефера)™. Contains other elements than Prebiotics in its composition
  • Preorbotic™. Contains other elements than Prebiotics in its composition
  • Probioline™. Contains other elements than Prebiotics in its composition
  • Proinuline
  • Reduc-Té™. Contains other elements than Prebiotics in its composition
  • Seidibiotics Plus. Complemento alimenticio simbiótico oral™. Contains other elements than Prebiotics in its composition
  • Seidygel Pre™. Contains other elements than Prebiotics in its composition
  • Symbiolact™. Contains other elements than Prebiotics in its composition
  • Symbiovag™. Contains other elements than Prebiotics in its composition
  • Tamalax Digestion™. Contains other elements than Prebiotics in its composition

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0 %
Molecular weight Inulin: 6.180 daltons
Inulin: 2 - 4 hours

References

  1. Wiciński M, Sawicka E, Gębalski J, Kubiak K, Malinowski B. Human Milk Oligosaccharides: Health Benefits, Potential Applications in Infant Formulas, and Pharmacology. Nutrients. 2020 Jan 20;12(1). pii: E266. Abstract Full text (link to original source)
  2. Cucalón Arenal JM, Blay Cortés MG. Actualización en probióticos, prebióticos y simbióticos para el médico de familia (I) Med Gen Fam. 2020; 9(5): 243-251 Full text (link to original source) Full text (in our servers)
  3. Nolan LS, Rimer JM, Good M. The Role of Human Milk Oligosaccharides and Probiotics on the Neonatal Microbiome and Risk of Necrotizing Enterocolitis: A Narrative Review. Nutrients. 2020 Oct 6;12(10). pii: E3052. Abstract Full text (link to original source)
  4. Bering SB. Human Milk Oligosaccharides to Prevent Gut Dysfunction and Necrotizing Enterocolitis in Preterm Neonates. Nutrients. 2018 Oct 8;10(10). pii: E1461. Abstract Full text (link to original source)
  5. Gibson GR, Hutkins R, Sanders ME, Prescott SL, Reimer RA, Salminen SJ, Scott K, Stanton C, Swanson KS, Cani PD, Verbeke K, Reid G. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol. 2017 Aug;14(8):491-502. Abstract Full text (link to original source)
  6. Bode L. The functional biology of human milk oligosaccharides. Early Hum Dev. 2015 Nov;91(11):619-22. Abstract
  7. Corzo N, Alonso JL, Azpiroz F, Calvo MA, Cirici M, Leis R, Lombó F, Mateos-Aparicio I, Plou FJ, Ruas-Madiedo P, Rúperez P, Redondo-Cuenca A, Sanz ML, Clemente A. Consenso científico sobre prebióticos. None 2014 Full text (link to original source) Full text (in our servers)
  8. Bode L. Human milk oligosaccharides: every baby needs a sugar mama. Glycobiology. 2012 Sep;22(9):1147-62. Abstract Full text (link to original source)

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