Last update Aug. 24, 2020

Praziquantel

Compatible

Safe product and/or breastfeeding is the best option.

Praziquantel is an anthelmintic with a broad spectrum that is used to treat cysticercosis, diphyllobothriasis, taeniasis, hymenolepiasis, schistosomiasis and fascioliasis.
Oral administration in one to three doses, one or two days (fourteen days for neurocysticercosis).

It is excreted in breast milk in clinically insignificant amounts (Bustinduy 2020, Pütter 1979).

Several medical societies, experts and expert consensus, consider the use of this medication to be safe or very probably safe during breastfeeding (Friedman 2018, Olds 2003, Porto 2003).
List of WHO essential medicines: compatible with breastfeeding (WHO / UNICEF 2002).

Alternatives

We do not have alternatives for Praziquantel since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Praziquantel in other languages or writings:

Group

Praziquantel belongs to this group or family:

Tradenames

Main tradenames from several countries containing Praziquantel in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 80 %
Molecular weight 312 daltons
Protein Binding 80 - 85 %
pKa 19.38 -
Tmax 1 - 3 hours
T½ 1 - 1.5 hours
M/P ratio 0.25 -
Theoretical Dose 0.028 mg/Kg/d
Relative Dose 0.05 %
Ped.Relat.Dose 0.047 %

References

  1. Bustinduy AL, Kolamunnage-Dona R, Mirochnick MH, Capparelli EV, Tallo V, Acosta LP, Olveda RM, Friedman JF, Hope WW. Population Pharmacokinetics of Praziquantel in Pregnant and Lactating Filipino Women Infected with Schistosoma japonicum. Antimicrob Agents Chemother. 2020 Aug 20;64(9). pii: e00566-20. Abstract Full text (link to original source)
  2. Friedman JF, Olveda RM, Mirochnick MH, Bustinduy AL, Elliott AM. Praziquantel for the treatment of schistosomiasis during human pregnancy. Bull World Health Organ. 2018 Jan 1;96(1):59-65. Abstract Full text (link to original source)
  3. Pérez JL, Carranza C, Mateos F. Antiparasitarios. Revisión de los fármacos útiles en el tratamiento de parasitosis clásicas y emergentes. \ [Antiparasitic drugs. Review of the useful drugs in the treatment of classic and emergent parasitic diseases]. Rev Esp Quimioter. 2009 Jun;22(2):93-105. Review. Spanish. Abstract Full text (link to original source) Full text (in our servers)
  4. Porto I. Antiparasitic drugs and lactation: focus on anthelmintics, scabicides, and pediculicides. J Hum Lact. 2003 Abstract
  5. Olds GR. Administration of praziquantel to pregnant and lactating women. Acta Trop. 2003 May;86(2-3):185-95. Review. Abstract
  6. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  7. Pütter J, Held F. Quantitative studies on the occurrence of praziquantel in milk and plasma of lactating women. Eur J Drug Metab Pharmacokinet. 1979;4(4):193-8. Abstract

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