Polymyxin B Sulfate

A

A group of polyketide antibiotics produced by various strains of Bacillus polymyx. Used topically in the treatment of skin, ear and eye infections and parenterally in Pseudomonas aeruginosa infections and other serious infections caused by multidrug-resistant germs. ^{(Coria 2011, Kwa 2007)}

At the time of last update, we found no published data on its excretion in breast milk.

The small dose and low plasma absorption of most topical ophthalmological, otological and dermatological preparations make it unlikely that significant amounts will pass into breast milk.

Because of their protein structure, oropharyngeal preparations are destroyed in the gastrointestinal tract and do not enter the bloodstream. ^(DrugBank)

Its high molecular weight makes passage into milk of significant amounts unlikely.

Polymyxin E or colistin, with a very similar molecular structure, is excreted in milk in non-significant amounts.

Its lack of oral bioavailability means that there is little or no passage into infant plasma from ingested breast milk.

Authorised parenteral use in paediatrics and neonatology for severe infections. ^(Martindale)

Do not apply to the breast or clean thoroughly before breast-feeding.

Avoid application of creams, gels and other locally applied products containing paraffin (mineral oil) on the nipple to prevent absorption by the infant. ^{(Concin 2008, Noti 2003)}

Several medical societies and expert authors consider the use of this medication safe during breastfeeding. ^{(LactMed, Hale, Briggs 2015, Schaefer 2015, Leachman 2006)}

See below the information of this related product:

• Colistin Sulfate (Polymyxin E) (Safe product and/or breastfeeding is the best option.)