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Pizotifen is a sedative antihistamine with weak antimuscarinic properties and a potent serotonin and tryptamine antagonist indicated for migraine prophylaxis. It is also used as an appetite stimulant. Oral administration in one to three daily doses.
Since the last update we have not found published data on its excretion in breastmilk.
Its pharmacokinetic data (very high percentage of protein binding and very wide volume of distribution) make it highly unlikely that significant quantities will pass into breast milk.
Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable (Davanzo 2014), especially during the neonatal period and in the event of prematurity.