Last update Oct. 14, 2022

Piperacillin Sodium

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Ureidopenicillin with a similar use to ticarcillin. Indicated in the treatment of infections caused by Pseudomonas aeruginosa, and by other susceptible bacteria. Intravenous administration.

It is excreted into breastmilk in a clinically insignificant amount. (Wyeth 2007, Baier 1982 (in LacMed), Chaplin 1982 (in Hale))

Because it lacks of oral bioavailability, seems difficult any pass to the infant’s plasma through the breast milk ingested, except on premature infants and immediate neonatal period, in which there may be an increased intestinal permeability.

Authorized use in infants and small infants. (Chen 2009)

Although rare, the possibility of transient gastroenteritis due to alteration of the intestinal flora in infants whose mothers take antibiotics should be taken into account. (Ito 1993).

Expert authors consider the use of this medication to be safe during breastfeeding. (Hale, LacMed, Briggs 2015)


See below the information of this related product:

Alternatives

We do not have alternatives for Piperacillin Sodium since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

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Piperacillin Sodium in other languages or writings:

Group

Piperacillin Sodium belongs to this group or family:

Tradenames

Main tradenames from several countries containing Piperacillin Sodium in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 536 daltons
Protein Binding 30 %
VD 0.2 l/Kg
pKa 3.49 -
Tmax 0.5 - 0.9 hours
0.7 - 1.2 hours
Theoretical Dose 0.29 mg/Kg/d
Relative Dose 0.1 - 0.2 %
Ped.Relat.Dose 0.13 - 0.2 %

References

  1. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on March 17, 2022 Full text (link to original source)
  2. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on March 15, 2022 Full text (link to original source)
  3. AEMPS. Piperacilina-Tazobactam. Ficha técnica 2015 Full text (in our servers)
  4. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  5. Chen HN, Lee ML, Yu WK, Lin YW, Tsao LY. Late-onset Enterobacter cloacae sepsis in very-low-birth-weight neonates: experience in a medical center. Pediatr Neonatol. 2009 Abstract
  6. Wyeth. Piperacillin & Tazobactam Product Information. 2007 Full text (in our servers)
  7. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  8. Baier R, Wolnik L, Puppel H et al. Piperacillin concentrations in milk and serum from lactating women. Proc ICAAC. 1982;203. Abstract 779 (in https://toxnet.nlm.nih.gov/newtoxnet/lactmed.htm) 1982
  9. Chaplin S, Sanders GL, Smith JM. Drug excretion in human breast milk. Adv Drug React Acute Poisoning Rev 1982; 1:255-87. 1982
  10. Tjandramaga TB, Mullie A, Verbesselt R, De Schepper PJ, Verbist L. Piperacillin: human pharmacokinetics after intravenous and intramuscular administration. Antimicrob Agents Chemother. 1978 Abstract

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