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An analgesic and pyrazolone derivative which inhibits prostaglandin synthesis.
It has been used as an analgesic and systemic antipyretic but given the frequency and severity of its side effects, the majority of products currently on the market are made for dermatological or otological topical application.
Administered orally to mothers, it is excreted in breastmilk in amounts which could be significant (Berlin 1982).
Hemolytic anemia has been observed in a newborn whose mother was taking a phenazone derivative (Frei 1985).
Systemic use (orally) is contraindicated during breastfeeding.
TOPICAL USE:
The small dose and low plasma absorption of most topical dermatological and otic preparations make it unlikely that it will transfer into breastmilk in significant amounts.
Topical use is compatible with breastfeeding.