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Non-steroidal anti-inflammatory drug (NSAID) derived from pyrazolone. It also has antipyretic and analgesic properties.
Effective in the treatment of almost all osteoarticular conditions. Due to its hematological toxicity, it should be reserved as a second-line drug when other drugs have failed.
Oral or topical cutaneous administration maximum one week.
Since the last update we have not found any published data on its excretion in breast milk.
Its pharmacokinetic data (high percentage of protein binding and low pKa) makes transfer into breastmilk in significant quantities unlikely.
Only negligible absorption was seen following application of phenylbutazone to the skin of humans (Aarbakke 1978). The dermatological use of phenylbutazone is compatible with breastfeeding.
Due to its serious possible side effects, it has been withdrawn from the market in many countries.
American Academy of Pediatrics: medication usually compatible with breastfeeding (AAP 2001).
Until there is further published data on this drug in relation to breastfeeding, known safer alternatives may be preferable, especially during the neonatal period and in cases of prematurity.