Last update June 28, 2022


High Risk

Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment.

Pemoline is a central nervous system (CNS) stimulant with actions similar to those of dexamfetamine. It has been used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. It has been withdrawn from the market in many countries due to its hepatotoxicity. (Formulary Watch 2005, Safer 2001)

Since the last update we have not found published data on its excretion in breastmilk.

Its pharmacokinetic data (low molecular weight and low percentage of plasma protein binding) makes it likely that significant amounts will pass into breast milk.




  • Dexamfetamine Sulfate (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Methylphenidate ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Modafinil (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Pemoline is also known as

Pemoline in other languages or writings:


Pemoline belongs to this group or family:


Main tradenames from several countries containing Pemoline in its composition:


Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 176 daltons
Protein Binding 50 %
Tmax 4 hours
12 hours


  1. Safer DJ, Zito JM, Gardner JE. Pemoline hepatotoxicity and postmarketing surveillance. J Am Acad Child Adolesc Psychiatry. 2001 Jun;40(6):622-9. Abstract
  2. Formulary Watch. Pemoline removed from US market. Formulary Watch. November 1, 2005 Full text (link to original source) Full text (in our servers)

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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America

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