Last update March 9, 2021
Very Low Risk
Non-steroidal anti-inflammatory drug (NSAID) that functions as a selective inhibitor of the cyclooxygenase-2 (COX-2) enzyme. It is a prodrug that is metabolized into valdecoxib, which was withdrawn from the market on 2005 due to cardiovascular toxicity after chronic use.
Prescribed for the limited and short-term treatment of postoperative pain.
Intravenous or intramuscular administration given every 6 to 12 hours and for a maximum of three days.
Its pharmacokinetic data (wide volume of distribution and high percentage of protein binding) explain the observed null or negligible passage to milk, that is not clinically significant (Paech 2012, EMA 2012).
No problems have been reported in infants of mothers given a single dose (Paech 2012).
A limited and short-term treatment administered at a minimum therapeutic dose can be regarded as compatible with breastfeeding.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM