Last update Jan. 20, 2015


Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Proteolytic enzyme from Carica papaya. It is used in food industry as a meat softener. Doubtfully effective as anti-inflammatory and GI tract medication.


We do not have alternatives for Papain.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Papain is also known as


Papain belongs to these groups or families:


Main tradenames from several countries containing Papain in its composition:


Variable Value Unit
Molecular weight 23.000 daltons


  1. Rosenthal AP, Blønd MB. [The enzyme papain in industry and food causes allergic sensitization]. Ugeskr Laeger. 2008 Abstract
  2. Lee J, Anderson R. Best evidence topic report. Proteolytic enzymes for oesophageal meat impaction. Emerg Med J. 2005 Abstract Full text (link to original source) Full text (in our servers)
  3. Ncube TN, Greiner T, Malaba LC, Gebre-Medhin M. Supplementing lactating women with puréed papaya and grated carrots improved vitamin A status in a placebo-controlled trial. J Nutr. 2001 Abstract Full text (link to original source) Full text (in our servers)
  4. Kinlay JR, O'Connell DL, Kinlay S. Risk factors for mastitis in breastfeeding women: results of a prospective cohort study. Aust N Z J Public Health. 2001 Abstract
  5. Maini S, Rudralingam M, Zeitoun H, Osbourne JE. Aspiration pneumonitis following papain enzyme treatment for oesophageal meat impaction. J Laryngol Otol. 2001 Abstract
  6. Bourdy G, Walter A. Maternity and medicinal plants in Vanuatu. I. The cycle of reproduction. J Ethnopharmacol. 1992 Abstract

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