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Pancreatic enzymes (such as pancreatin or pancrelipase) are preparations of mammalian (pig, ox) pancreas that contain enzymes that have protease, lipase, and amylase activity. They hydrolyze fats into glycerol and fatty acids, break down proteins into peptides and proteoses, and convert starch into dextrins and sugars. They are administered orally to treat malabsorption associated with exocrine pancreatic deficiencies, such as pancreatitis and cystic fibrosis.
At latest update no published data on excretion into breast milk was found.
Pancreatic enzymes act locally in the gastrointestinal tract and are not absorbed in significant amounts. (Vivus 2020, AEMPS 2012)
Its high molecular weight and insignificant intestinal absorption make its passage into breast milk very unlikely.
A low oral bioavailability hinders the passage into infant plasma from ingested breast milk.
It is a medication used in children and young infants.
The manufacturer considers this medicine compatible with breastfeeding. (Vivus 2020, AEMPS 2012)